H K S C 香港干细胞

最近有究硏指出，红斑狼疮的病人身体内的干细胞衰老速度比正常的细胞快。在身体中，干细胞扮演重要的角色，血管的产生是

由干细胞组织出来的，当干细胞容易衰老血管便不完整，在红斑狼疮常见的问题便是血管的炎症。

血管是由干细胞产生出来的，干细胞形成血管内皮细胞和周细胞，干细胞老化快了便不能产生完整的血管内皮。血管内皮不完整会产生血液的不正常凝固，血液不正常凝固便产生血管的炎症。

红斑狼疮的关节炎和肾炎同样是由血管炎引起。

王启元医生

Clin Dev Immunol. 2013;2013:134243. doi: 10.1155/2013/134243. Epub 2013 Sep 16.
p53/p21 Pathway involved in mediating cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients.
Gu Z, Jiang J, Tan W, Xia Y, Cao H, Meng Y, Da Z, Liu H, Cheng C.
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Abstract

Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE. Numerous studies have shown that activation of the p53/p21 pat hway inhibits the proliferation of BM-MSCs. The aim of this study was to determine whether p53/p21 pathway is involved in regulating the aging of BM-MSCs from SLE patients and the underlying mechanisms. We further confirmed that BM-MSCs from SLE patients showed characteristics of senescence. The expressions of p53 and p21 were significantly increased, whereas levels of Cyclin E, cyclin-dependent kinase-2, and phosphorylation of retinoblastoma protein were decreased in the BM-MSCs from SLE patients and knockdown of p21 expression reversed the senescent features of BM-MSCs from SLE patients. Our results demonstrated that p53/p21 pathway played a n important role in the senescence process of BM-MSCs from SLE.